Kuyambitsa PQQ: The Ultimate Energy Booster kwa Malingaliro ndi Thupi

Kuyambitsa PQQ: The Ultimate Energy Booster kwa Malingaliro ndi Thupi

Pyrroloquinoline quinone, yotchedwa PQQ, ndi gulu latsopano lopanga ma prosthetic lomwe lili ndi magwiridwe antchito ofanana ndi ma vitamini. Amapezeka kwambiri mu prokaryotes, zomera ndi nyama zoyamwitsa, monga soya wothira kapena natto, tsabola wobiriwira, zipatso za kiwi, Parsley, tiyi, papaya, sipinachi, udzu winawake, mkaka wa m'mawere, ndi zina zotero.

M'zaka zaposachedwa, PQQ yakhala imodzi mwazakudya za "nyenyezi" zomwe zakopa chidwi chambiri. Mu 2022 ndi 2023, dziko langa lidavomereza PQQ yopangidwa ndi kaphatikizidwe ndi kuthirira ngati chakudya chatsopano.

Ntchito zachilengedwe za PQQ zimakhazikika m'magawo awiri. Choyamba, imatha kuthandizira kukula ndi chitukuko cha mitochondria ndikulimbikitsa kukula kwa maselo aumunthu; chachiwiri, ili ndi zinthu zabwino za antioxidant, zomwe zingathandize kuchotsa ma free radicals ndi kuchepetsa kuwonongeka kwa maselo. Ntchito ziwirizi zimapangitsa kuti ikhale ndi gawo lalikulu paumoyo waubongo, thanzi lamtima, thanzi la metabolic ndi zina. Chifukwa thupi la munthu silingathe kupanga PQQ palokha, liyenera kuwonjezeredwa kudzera muzakudya zowonjezera.

Udindo wa 01.PQQ pakuwongolera kuzindikira ndiwofunika kwambiri

Mu February 2023, ofufuza a ku Japan adafalitsa pepala lofufuzira lotchedwa "Pyrroloquinoline quinone disodium mchere umapangitsa kuti ubongo ugwire ntchito mwa achikulire ndi akuluakulu" mu magazini ya "Food & Function", poyambitsa chidziwitso cha PQQ pa achinyamata ndi achikulire ku Japan. Zotsatira zabwino za kafukufuku.

Kafukufukuyu anali mayeso oyendetsedwa ndi akhungu amtundu wapawiri omwe amaphatikiza amuna 62 athanzi aku Japan azaka 20-65, okhala ndi Mini-Mental State Scale scores ≥ 24, omwe adasungabe moyo wawo wakale panthawi yophunzira. Khamu la akazi. Maphunziro ofufuza adagawidwa mwachisawawa kukhala gulu lothandizira ndi gulu lolamulira la placebo, ndipo adaperekedwa pamlomo PQQ (20 mg / d) kapena makapisozi a placebo tsiku lililonse kwa masabata a 12. Njira yoyesera pa intaneti yopangidwa ndi kampani idagwiritsidwa ntchito pozindikiritsa masabata 0/8/12. Kuyeza kwachidziwitso kumayesa ntchito 15 zotsatirazi zaubongo.

Zotsatira zinawonetsa kuti poyerekeza ndi gulu lolamulira la placebo, pambuyo pa masabata a 12 a kudya kwa PQQ, kukumbukira kophatikizana ndi kukumbukira mawu amagulu onse ndi gulu la okalamba linakula; pambuyo pa masabata 8 a kudya kwa PQQ, kusinthasintha kwa chidziwitso cha gulu laling'ono, kuthamanga kwachangu komanso kuthamanga kwa Execution kunakula.

02 PQQ sikuti imangosintha magwiridwe antchito aubongo a okalamba, komanso imathandizira kuyankha kwaubongo kwa achinyamata!

Mu Marichi 2023, magazini yodziwika padziko lonse lapansi ya Food & Function idasindikiza pepala lofufuzira lotchedwa "Pyrroloquinoline quinone disodium mchere umathandizira ubongo kugwira ntchito mwa achikulire ndi achikulire". Kafukufukuyu adafufuza momwe PQQ imakhudzira magwiridwe antchito anzeru a akulu azaka 20-65, kukulitsa kuchuluka kwa kafukufuku wa PQQ kuchokera kwa okalamba kupita kwa achinyamata. Kafukufukuyu adatsimikizira kuti PQQ imatha kusintha magwiridwe antchito anzeru a anthu azaka zonse.

Kafukufuku wapeza kuti PQQ, monga chakudya chogwira ntchito, imatha kusintha ntchito zaubongo pazaka zilizonse, ndipo ikuyembekezeka kukulitsa kugwiritsa ntchito PQQ ngati chakudya chogwira ntchito kuchokera kwa okalamba kupita kwa anthu azaka zonse.

03 PQQ imagwira ntchito ngati choyambitsa "mafakitale amphamvu zama cell" kuti abwezeretse thanzi lawo

Mu Meyi 2023, Cell Death Dis idasindikiza pepala lofufuzira lotchedwa Kunenepa kwambiri kumapangitsa kuti munthu azitha kutengera cardiolipin-dependent mitophagy ndi chithandizo cha intercellular mitochondrial transfer cell of mesenchymal stem cell. Kafukufukuyu adapeza PQQ ndikuwunika ngati mphamvu ya intercellular mitochondrial yopereka anthu onenepa (anthu omwe ali ndi vuto la metabolic) komanso machiritso a ma mesenchymal stem cell (MSCs) ndi osokonekera, komanso ngati chithandizo cha mitochondrial chingawasinthe. Kusinthasintha kumabwezeretsa thanzi la mitochondrial kuti muchepetse vuto la mitophagy.
Kafukufukuyu akupereka kumvetsetsa koyamba kwa mamolekyu osokonekera a mitophagy m'maselo amtundu wa mesenchymal omwe amachokera ku kunenepa kwambiri ndipo akuwonetsa kuti thanzi la mitochondrial litha kubwezeretsedwanso kudzera mu malamulo a PQQ kuti muchepetse vuto la mitophagy.

04 PQQ imatha kukonza magwiridwe antchito a metabolic amunthu

Mu Meyi 2023, nkhani yowunikiranso yotchedwa "Pyrroloquinoline-quinone kuti muchepetse kuchuluka kwamafuta ndikuwonjezera kunenepa kwambiri" idasindikizidwa mu nyuzipepala ya Front Mol Biosci, yomwe idafotokoza mwachidule maphunziro 5 a nyama ndi maphunziro awiri a cell.
Zotsatira zikuwonetsa kuti PQQ imatha kuchepetsa mafuta amthupi, makamaka kuchuluka kwamafuta a visceral ndi chiwindi, potero kupewa kunenepa kwambiri. Kuchokera pakuwunika kwa mfundo, PQQ imaletsa makamaka lipogenesis ndikuchepetsa kudzikundikira kwamafuta powongolera ntchito ya mitochondrial ndikulimbikitsa kagayidwe ka lipid.

05 PQQ imatha kupewa kufooka kwa mafupa chifukwa cha ukalamba wachilengedwe

Mu Seputembala 2023, Aging Cell idasindikiza pepala lofufuzira lotchedwa "Pyrroloquinoline quinone imachepetsa kufooka kwa mafupa okhudzana ndi ukalamba kudzera mu buku la MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation" pa intaneti. Kafukufukuyu, kudzera pakuyesa mbewa, adapeza kuti zakudya zowonjezera za PQQ zimatha kupewa matenda a osteoporosis omwe amayamba chifukwa cha ukalamba wachilengedwe. Makina oyambira amphamvu amphamvu a antioxidant a PQQ amapereka maziko oyesera ogwiritsira ntchito PQQ ngati chowonjezera chazakudya popewa matenda okhudzana ndi ukalamba.
Kafukufukuyu akuwonetsa momwe PQQ imagwirira ntchito komanso njira zatsopano zopewera ndi kuchiza senile osteoporosis, ndikutsimikizira kuti PQQ itha kugwiritsidwa ntchito ngati chakudya chotetezeka komanso chothandiza popewa komanso kuchiza matenda a senile osteoporosis. Panthawi imodzimodziyo, zinadziwika kuti PQQ imayambitsa chizindikiro cha MCM3-Keap1-Nrf2 mu osteoblasts, transcriptionally imayang'anira mawu a ma jini a antioxidant ndi majini a Fbn1, amalepheretsa kupanikizika kwa okosijeni ndi osteoclast bone resorption, ndikulimbikitsa mapangidwe a mafupa a osteoblast, motero amaletsa kukalamba. udindo pazochitika za kugonana osteoporosis.

06 Kuphatikizira PQQ kumatha kuteteza ma cell a retinal ganglion ndikuwongolera thanzi lamaso!

Mu Seputembala 2023, magazini ya Acta Neuropathol Commun idasindikiza kafukufuku kuchokera kwa akatswiri odziwa zamaso ndi akatswiri a Eye Hospital of Karolinska Institutet ku Stockholm, Sweden, sukulu yodziwika bwino yachipatala yaku Europe, komanso Royal Victoria Eye and Ear Hospital ku Australia, ndi dipatimenti ya Biology ya University of Pisa ku Italy. Imatchedwa "Pyrroloquinoline quinone imayendetsa ATP synthesis mu vitro ndi mu vivo ndipo imapereka retinal ganglion cell neuroprotection." Kafukufuku watsimikizira kuti PQQ imakhala ndi chitetezo pama cell a retinal ganglion (RGC) ndipo ili ndi kuthekera kwakukulu ngati neuroprotective wothandizira watsopano pokana retinal ganglion cell apoptosis.
Zomwe zapezazi zimathandizira gawo lomwe PQQ lingakhalepo ngati chida chowoneka bwino cha neuroprotective chomwe chingathandizire kulimba kwa ma cell a retinal ganglion ndikuchepetsa chiwopsezo cha zotsatirapo. Nthawi yomweyo, ofufuza amakhulupirira kuti kuwonjezera PQQ ndi njira yabwino yosungira maso.

07 Kuphatikizira PQQ kumatha kuwongolera kumera kwamatumbo, kukonza magwiridwe antchito a chithokomiro, ndikuchepetsa kuwonongeka kwa chithokomiro.

Mu Disembala 2023, gulu lofufuza kuchokera ku Shanghai Tenth People's Hospital ku Tongji University School of Medicine lidafalitsa nkhani yakuti "The Potential Role of Pyrroloquinoline Quinone to Regulate Thyroid Function and Gut Microbiota Composition of Graves ' Disease in Mice" mu magazini ya Pol J Microbiol M'nkhaniyi, ofufuza akuwonetsa kuti mbewa ya flora ya QQ inagwiritsidwa ntchito powonjezera mbewa. kuchepetsa matumbo kuwonongeka, ndi kusintha chithokomiro ntchito.
Kafukufukuyu adapeza zotsatira za PQQ supplementation pa GD mbewa ndi zomera zawo zam'mimba:

01 Pambuyo pa PQQ supplementation, seramu TSHR ndi T4 ya mbewa za GD zinachepetsedwa, ndipo kukula kwa chithokomiro kunachepetsedwa kwambiri.

02 PQQ imachepetsa kutupa ndi kupsinjika kwa okosijeni, komanso imachepetsa kuwonongeka kwa epithelial yaing'ono yamatumbo.

03 PQQ imakhudza kwambiri kubwezeretsanso kusiyanasiyana ndi kapangidwe ka microbiota.

04 Poyerekeza ndi gulu la GD, chithandizo cha PQQ chikhoza kuchepetsa kuchuluka kwa Lactobacilli mu mbewa (ichi ndi chithandizo chomwe chingathe kutsata ndondomeko ya GD).

Mwachidule, PQQ supplementation imatha kuwongolera magwiridwe antchito a chithokomiro, kuchepetsa kuwonongeka kwa chithokomiro, ndikuchepetsa kutupa ndi kupsinjika kwa okosijeni, potero kumachepetsa kuwonongeka kwamatumbo am'mimba. Ndipo PQQ imatha kubwezeretsanso mitundu yosiyanasiyana yamaluwa am'mimba.

Kuphatikiza pa maphunziro omwe ali pamwambawa akutsimikizira gawo lofunikira komanso kuthekera kopanda malire kwa PQQ ngati chowonjezera pazakudya kuti munthu akhale wathanzi, maphunziro am'mbuyomu apitilizanso kutsimikizira ntchito zamphamvu za PQQ.

08 PQQ imatha kusintha kuthamanga kwa magazi

Mu Okutobala 2022, pepala lofufuzira lotchedwa "Pyrroloquinoline quinone (PQQ) imathandizira pulmonary hypertension powongolera mitochondrial ndi metabolic ntchito" idasindikizidwa mu nyuzipepala ya Pulmonary Pharmacology & Therapeutics, ndicholinga chofufuza ntchito ya PQQ pakuwongolera matenda oopsa a m'mapapo.
Zotsatira zikuwonetsa kuti PQQ imatha kuchepetsa zovuta za mitochondrial komanso zovuta za metabolic m'maselo osalala a mitsempha ya m'mapapo ndikuchedwetsa kufalikira kwa matenda oopsa a m'mapapo mu makoswe; Chifukwa chake, PQQ itha kugwiritsidwa ntchito ngati chithandizo chothandizira kuchiza matenda a pulmonary hypertension.

09 PQQ imatha kuchedwetsa kukalamba kwa maselo ndikuwonjezera moyo!

Mu Januware 2020, pepala lofufuzira lotchedwa Pyrroloquinoline quinone idachedwetsa kutukusira komwe kumabwera chifukwa cha TNF-α kudzera mu p16/p21 ndi njira zowonetsera za Jagged1 zomwe zidasindikizidwa mu Clin Exp Pharmacol Physiol zidatsimikizira mwachindunji za anti-kukalamba za PQQ m'maselo amunthu. , zotsatira zake zikuwonetsa kuti PQQ imachedwetsa kukalamba kwa maselo amunthu ndipo imatha kutalikitsa moyo.

Ofufuza adapeza kuti PQQ imatha kuchedwetsa kukalamba kwa maselo amunthu, ndikutsimikiziranso izi kudzera muzotsatira zama biomarkers angapo monga p21, p16, ndi Jagged1. Akuti PQQ ikhoza kupititsa patsogolo thanzi la anthu onse ndikuwonjezera moyo wautali.

10 PQQ imatha kupewa kukalamba kwa ovarian ndikusunga chonde

Mu Marichi 2022, pepala lofufuzira lotchedwa "PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice" lidasindikizidwa mu nyuzipepala ya Front Endocrinol, ndicholinga chofufuza ngati zakudya za PQQ zimateteza ku vuto la ovarian lomwe limayambitsa alkylating. zotsatira.
Zotsatira zake zidawonetsa kuti PQQ supplementation idachulukitsa kulemera ndi kukula kwa thumba losunga mazira, idabwezeretsa pang'ono mayendedwe owonongeka a estrous, ndikuletsa kutayika kwa ma follicles mu mbewa zothandizidwa ndi alkylating agents. Kuphatikiza apo, PQQ supplementation idakulitsa kwambiri kuchuluka kwa mimba ndi kukula kwa zinyalala pakubereka mu mbewa zothandizidwa ndi alkylating. Zotsatira izi zikuwonetsa kuthekera kolowererapo kwa PQQ supplementation mu alkylating agent-induced ovarian dysfunction.

Mapeto
M'malo mwake, monga chowonjezera chatsopano chazakudya, PQQ yadziwika chifukwa cha zabwino zake pazakudya komanso thanzi. Chifukwa cha ntchito zake zamphamvu, chitetezo chokwanira komanso kukhazikika kwabwino, ili ndi chiyembekezo chokulirapo pankhani yazakudya zogwira ntchito.
M'zaka zaposachedwa, ndikukula kwa chidziwitso, PQQ yapeza chiphaso chokwanira kwambiri ndipo imagwiritsidwa ntchito kwambiri ngati chakudya chowonjezera kapena chakudya ku United States, Europe ndi mayiko ena ndi zigawo. Pomwe kuzindikira kwa ogula kunyumba kukukulirakulira, akukhulupirira kuti PQQ, monga chopangira chatsopano, ipanga dziko latsopano pamsika wapakhomo.

Zolozera:

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