Quercetin, mankhwala opangidwa ndi flavonoid omwe amapezeka kwambiri muzakudya zosiyanasiyana zochokera ku mbewu monga anyezi, maapulo, ndi zipatso, akhala akugwiritsidwa ntchito kwambiri pofufuza zasayansi komanso kukambirana zaumoyo, chifukwa champhamvu yake yoteteza antioxidant, anti-inflammatory, ndi zina zosiyanasiyana zamoyo. Komabe, kusungunuka kwake kosakwanira m'madzi kumalepheretsa kuyamwa kwake ndi kugwiritsidwa ntchito kwake m'thupi la munthu, motero kumachepetsa kukwaniritsidwa kwabwino kwa thanzi. M'zaka zaposachedwa, ndi kupita patsogolo kosalekeza kwa sayansi ndi ukadaulo, quercetin yosungunuka m'madzi yatuluka, kuthana ndi zovuta zosungunuka za quercetin yachikhalidwe ndikuwonetsa kuchuluka kwa ntchito ndi maubwino apadera.
Traditional Quercetin, chifukwa cha kusungunuka kwake m'madzi otsika, amavutika kuti asungunuke m'matumbo am'mimba pambuyo pakamwa, zomwe zimapangitsa kuti mayamwidwe ake azikhala otsika kwambiri. Kafukufuku akuwonetsa kuti mayamwidwe ake m'matumbo ndi pafupifupi 2%. Mosiyana ndi izi, quercetin yosungunuka m'madzi imagwiritsa ntchito matekinoloje apamwamba kwambiri, monga ukadaulo wa nanomiclle ndi ukadaulo wa cyclodextrin, kuti apititse patsogolo kwambiri kusungunuka kwake m'madzi. Mwachitsanzo, Dryland New Materials Laboratory ya South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Sciences, inakonza bwino ma nanomicell odzaza ndi quercetin kudzera mu njira zophatikizira mankhwala. Izi zidapangitsa kuti quercetin asungunuke kwambiri m'madzi, ma photostability, komanso kugwiritsa ntchito bwino ma cellular. Zotsatira zake, quercetin imatha kusungunuka bwino m'madzi am'mimba, ndikuwonjezera malo omwe amalumikizana ndi ma cell am'matumbo am'mimba ndikuwonjezera kuyamwa kwake m'thupi la munthu. Kafukufuku wofunikira akuwonetsa kuti bioavailability ya quercetin yosungunuka m'madzi imatha kukulitsidwa kangapo kapena kupitilira apo poyerekeza ndi quercetin yachikhalidwe, zomwe zimapangitsa kuti thupi lizitha kuyamwa bwino ndikugwiritsa ntchito zigawo zogwira ntchito za quercetin ndikutsegula mokwanira zotsatira zake zolimbikitsa thanzi.
1. Kuwongolera kwa Glucose wa Magazi
Quercetin yosungunuka m'madzi imapereka chiyembekezo chatsopano kwa anthu omwe akhudzidwa ndi thanzi la shuga. Kafukufuku wopangidwa ndi Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, awonetsa kuti quercetin, kuphatikiza ndi zipatso zina za flavonoids, imatha kuletsa ntchito ya α-glucosidase. α-Glucosidase imagwira ntchito yofunika kwambiri mu hydrolysis ya chakudya, ndipo kuletsa ntchito yake kumatha kulepheretsa chimbudzi ndi kuyamwa kwa chakudya, potero kumathandizira kuwongolera kuchuluka kwa shuga m'magazi a postpandial. Ndi kusungunuka kwake kwabwino kwambiri komanso kuyamwa kwake, quercetin yosungunuka m'madzi imatha kutenga nawo gawo pakuletsa kwa α-glucosidase, ndikupereka chithandizo champhamvu pakupanga zinthu zogwira ntchito zomwe zimayang'anira shuga wamagazi a postprandial. Izi zimakhala ndi tanthauzo lalikulu pakuwongolera thanzi latsiku ndi tsiku kwa odwala matenda ashuga kapena omwe ali ndi vuto losinthasintha lamagazi a glucose.
2. Chitetezo cha Chiwindi
quercetin yosungunuka m'madzi imawalanso pakusunga thanzi lachiwindi. Kafukufuku wopangidwa ndi gulu la Pulofesa Peng Cheng waku Chengdu University of Traditional Chinese Medicine wawonetsa kuti quercetin imatha kuwongolera chiwindi chamafuta oledzeretsa mwa kuyimira pakati pakusamutsa kwa nyukiliya kwa TFEB kuti alipire kusakwanira kwa autophagy. Kuwonjezeka kwa mphamvu ya quercetin yosungunuka m'madzi kumapangitsa kuti ifike pachiwindi mwachangu komanso moyenera, kulimbikitsa ntchito ya autophagic ya maselo a chiwindi, kulimbikitsa kagayidwe ka mafuta m'chiwindi, ndikuthandizira kuchotsa zinthu zovulaza. Izi zimathandiza kupewa ndi kukonza matenda osiyanasiyana a chiwindi, monga mafuta a chiwindi ndi matenda a chiwindi cha mowa, pochepetsa kuwonongeka kwa mowa ndi zinthu zina m'chiwindi.
3. Kulimbikitsa Kutsitsimutsa Tsitsi
Kumeta tsitsi ndizovuta kwambiri kwa anthu ambiri, ndipo quercetin yosungunuka m'madzi imapereka njira yatsopano yothetsera vutoli. Kafukufuku wothandizana ndi gulu la Pulofesa Qu Jing wochokera ku Institute of Zoology, Chinese Academy of Sciences, apeza kuti quercetin imatha kulimbikitsa kumeranso kwa tsitsi mwa kuyambitsa njira ya HIF-1 m'maselo a endothelial a follicle microenvironment ya tsitsi. quercetin yosungunuka m'madzi imatha kulowa m'magazi mosasunthika ndikufikira kudera latsitsi, ndikuyika mphamvu zake pakuwongolera tsitsi la microenvironment. Zimapangitsa kusiyana ndi kufalikira kwa maselo amtundu wa tsitsi, motero kumalimbikitsa kukula kwa tsitsi. Kaya kutayika kwa tsitsi kumayamba chifukwa cha kupsinjika, kusalinganika kwa mahomoni, kapena zinthu zina, quercetin yosungunuka m'madzi imakhala ndi lonjezo ngati chithandizo chotetezeka komanso chothandiza.
4. Kupititsa patsogolo chitetezo cha mthupi
Quercetin palokha imakhala ndi zinthu zina zoteteza thupi, monga kulimbikitsa kuyambitsa kwa macrophage komanso kutulutsa kwazinthu zokhudzana ndi chitetezo chamthupi. Kubwera kwa quercetin wosungunuka m'madzi kumakulitsanso zabwino izi. Kusungunuka kwake m'madzi kumapangitsa kuti thupi likhale lofanana kwambiri, zomwe zimathandiza kuti lizigwira ntchito bwino pazigawo zosiyanasiyana za chitetezo cha mthupi. Imawonjezera ntchito ya maselo a chitetezo chamthupi ndipo imathandizira kubisala kwa chitetezo chamthupi monga chotupa necrosis factor-α ndi interferon-γ, kuthandiza thupi kuteteza bwino ku tizilombo toyambitsa matenda akunja komanso kukulitsa chitetezo chokwanira. Izi zimapereka mphamvu kwa anthu kukhala olimba mtima akakumana ndi zoopsa zaumoyo monga ma virus a chimfine ndi matenda a bakiteriya.
Kukonzekera kwa quercetin wosungunuka m'madzi makamaka kumagwiritsa ntchito njira zaukadaulo zotetezeka komanso zokomera zachilengedwe, monga ukadaulo wa nanomiclle womwe tatchula kale. Njirazi zimathandizira kusungunuka kwamadzi kwa quercetin popanda kuyambitsa mankhwala owopsa, kuwonetsetsa kuti mankhwalawa ndi otetezeka. Kuphatikiza apo, chifukwa chakukula kwa bioavailability, mlingo wocheperako wa quercetin umafunika kuti upeze phindu laumoyo womwewo, ndikuchepetsanso chiwopsezo cha zovuta zomwe zingachitike.
Ndikukula kosalekeza kwa kafukufuku komanso kupangika kwaukadaulo kwanthawi zonse, quercetin yosungunuka m'madzi ili pafupi kuwonetsa kuthekera kwakukulu kogwiritsa ntchito zakudya zogwira ntchito, zakudya zopatsa thanzi, zodzoladzola, ndi makampani opanga mankhwala. Pazakudya zogwira ntchito, zitha kuphatikizidwa muzakumwa zosiyanasiyana komanso zokhwasula-khwasula, zomwe zimapatsa ogula chitetezo choyenera chaumoyo. M'makampani odzola zodzoladzola, kugwiritsa ntchito mphamvu zake zotsitsimutsa tsitsi komanso antioxidant, zinthu zomwe zimakhala ndi ntchito monga zoletsa tsitsi komanso kukalamba kwapakhungu zimatha kupangidwa. M'munda wamankhwala, pali lonjezo lalikulu lopitiliza kufufuza ntchito zake pochiza matenda osachiritsika ndikuthandizira chithandizo chamankhwala, ndikutsegula njira zatsopano zofufuzira zachipatala ndi zaumoyo.
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